Fc functional antibodies in humans with severe H7N9 and seasonal influenza

HA Vanderven; L Liu; F Ana-Sosa-Batiz; THO Nguyen; Y Wan; B Wines; P Mark Hogarth; D Tilmanis; A Reynaldi; MS Parsons; AC Hurt; MP Davenport; T Kotsimbos; AC Cheng; K Kedzierska; X Zhang; J Xu; SJ Kent

Journal article

Fc functional antibodies in humans with severe H7N9 and seasonal influenza

HA Vanderven, L Liu, F Ana-Sosa-Batiz, THO Nguyen, Y Wan, B Wines, P Mark Hogarth, D Tilmanis, A Reynaldi, MS Parsons, AC Hurt, MP Davenport, T Kotsimbos, AC Cheng, K Kedzierska, X Zhang, J Xu, SJ Kent

Journal of Clinical Investigation | AMER SOC CLINICAL INVESTIGATION INC | Published : 2017

DOI: 10.1172/jci.insight.92750

Abstract

BACKGROUND. Both seasonal and novel avian influenza viruses can result in severe infections requiring hospitalization. Anti-influenza antibodies (Abs) with Fc-mediated effector functions, such as Ab-dependent cellular cytotoxicity (ADCC), are of growing interest in control of influenza but have not previously been studied during severe human infections. As such, the objective of this study was to examine Fc-mediated Ab functions in humans hospitalized with influenza infection. METHODS. Serum Ab response was studied in subjects hospitalized with either pandemic H7N9 avian influenza virus in China (n = 18) or circulating seasonal influenza viruses in Melbourne, Australia (n = 16). Recombinant ..

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University of Melbourne Researchers

Oanh Nguyen Author

Katherine Kedzierska Author

Stephen Kent Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

The National Health and Medical Research Council ([NHMRC] grants 1023294, 1041832, and 1071916), the Australian Department of Health, and the joint University of Melbourne/Fudan University International Research and Research Training Fund provided funding for this study.